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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1928 1
1949 1
1950 1
1953 3
1954 2
1957 3
1958 1
1962 2
1964 1
1966 2
1967 5
1968 9
1969 8
1970 4
1971 4
1972 11
1973 13
1974 14
1975 44
1976 38
1977 26
1978 39
1979 25
1980 43
1981 37
1982 52
1983 53
1984 52
1985 80
1986 65
1987 51
1988 68
1989 73
1990 62
1991 71
1992 78
1993 77
1994 93
1995 71
1996 77
1997 74
1998 68
1999 74
2000 80
2001 74
2002 103
2003 80
2004 82
2005 78
2006 67
2007 90
2008 82
2009 88
2010 111
2011 126
2012 126
2013 114
2014 108
2015 121
2016 147
2017 137
2018 140
2019 172
2020 187
2021 199
2022 175
2023 204
2024 91

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4,242 results

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Page 1
Asymmetrical nasal high flow ventilation improves clearance of CO(2) from the anatomical dead space and increases positive airway pressure.
Tatkov S, Rees M, Gulley A, van den Heuij LGT, Nilius G. Tatkov S, et al. J Appl Physiol (1985). 2023 Feb 1;134(2):365-377. doi: 10.1152/japplphysiol.00692.2022. Epub 2023 Jan 12. J Appl Physiol (1985). 2023. PMID: 36633864 Free PMC article.
Positive airway pressure that dynamically changes with breathing, and clearance of anatomical dead space are the key mechanisms of noninvasive respiratory support with nasal high flow (NHF). ...These findings are relevant to patients with elevated respiratory rates …
Positive airway pressure that dynamically changes with breathing, and clearance of anatomical dead space are the key mechanism …
A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid beta.
Iliff JJ, Wang M, Liao Y, Plogg BA, Peng W, Gundersen GA, Benveniste H, Vates GE, Deane R, Goldman SA, Nagelhus EA, Nedergaard M. Iliff JJ, et al. Sci Transl Med. 2012 Aug 15;4(147):147ra111. doi: 10.1126/scitranslmed.3003748. Sci Transl Med. 2012. PMID: 22896675 Free PMC article.
We demonstrate that a substantial portion of subarachnoid CSF cycles through the brain interstitial space. On the basis of in vivo two-photon imaging of small fluorescent tracers, we showed that CSF enters the parenchyma along paravascular spaces that surround penet …
We demonstrate that a substantial portion of subarachnoid CSF cycles through the brain interstitial space. On the basis of in vivo tw …
Molecular mechanisms of K(+) clearance and extracellular space shrinkage-Glia cells as the stars.
MacAulay N. MacAulay N. Glia. 2020 Nov;68(11):2192-2211. doi: 10.1002/glia.23824. Epub 2020 Mar 17. Glia. 2020. PMID: 32181522 Review.
Passive distribution of K(+) via Kir4.1-mediated spatial buffering of K(+) has become a favorite within the glial field, although evidence for a quantitatively significant contribution from this ion channel to K(+) clearance from the extracellular space is sparse. T …
Passive distribution of K(+) via Kir4.1-mediated spatial buffering of K(+) has become a favorite within the glial field, although evidence f …
The glymphatic pathway in neurological disorders.
Rasmussen MK, Mestre H, Nedergaard M. Rasmussen MK, et al. Lancet Neurol. 2018 Nov;17(11):1016-1024. doi: 10.1016/S1474-4422(18)30318-1. Lancet Neurol. 2018. PMID: 30353860 Free PMC article. Review.
BACKGROUND: The glymphatic (glial-lymphatic) pathway is a fluid-clearance pathway identified in the rodent brain in 2012. This pathway subserves the flow of CSF into the brain along arterial perivascular spaces and subsequently into the brain interstitium, facilitat …
BACKGROUND: The glymphatic (glial-lymphatic) pathway is a fluid-clearance pathway identified in the rodent brain in 2012. This pathwa …
The Brain's Glymphatic System: Current Controversies.
Mestre H, Mori Y, Nedergaard M. Mestre H, et al. Trends Neurosci. 2020 Jul;43(7):458-466. doi: 10.1016/j.tins.2020.04.003. Epub 2020 May 15. Trends Neurosci. 2020. PMID: 32423764 Free PMC article. Review.
Imaging studies, as well as manipulations of fluid transport, point to a key role of the glymphatic-lymphatic system in clearance of amyloid-beta and other proteins. As such, the glymphatic-lymphatic system represents a new target in combating neurodegenerative diseases. . …
Imaging studies, as well as manipulations of fluid transport, point to a key role of the glymphatic-lymphatic system in clearance of …
Imaging perivascular space structure and function using brain MRI.
Barisano G, Lynch KM, Sibilia F, Lan H, Shih NC, Sepehrband F, Choupan J. Barisano G, et al. Neuroimage. 2022 Aug 15;257:119329. doi: 10.1016/j.neuroimage.2022.119329. Epub 2022 May 21. Neuroimage. 2022. PMID: 35609770 Free PMC article. Review.
In this article, we provide an overview of current neuroimaging methods for studying perivascular spaces (PVS) in humans using brain MRI. In recent years, an increasing number of studies highlighted the role of PVS in cerebrospinal/interstial fluid circulation and clear …
In this article, we provide an overview of current neuroimaging methods for studying perivascular spaces (PVS) in humans using brain …
Fluid transport in the brain.
Rasmussen MK, Mestre H, Nedergaard M. Rasmussen MK, et al. Physiol Rev. 2022 Apr 1;102(2):1025-1151. doi: 10.1152/physrev.00031.2020. Epub 2021 May 5. Physiol Rev. 2022. PMID: 33949874 Free PMC article. Review.
Consequently, the brain depends on a special fluid [the cerebrospinal fluid (CSF)] that is flushed into brain along the unique perivascular spaces created by astrocytic vascular endfeet. We describe this pathway, coined the term glymphatic system, based on its dependency o …
Consequently, the brain depends on a special fluid [the cerebrospinal fluid (CSF)] that is flushed into brain along the unique perivascular …
The Glymphatic System: A Novel Component of Fundamental Neurobiology.
Hablitz LM, Nedergaard M. Hablitz LM, et al. J Neurosci. 2021 Sep 15;41(37):7698-7711. doi: 10.1523/JNEUROSCI.0619-21.2021. J Neurosci. 2021. PMID: 34526407 Free PMC article. Review.
As such, the glymphatic system plays a key role in regulating directional interstitial fluid movement, waste clearance, and, potentially, brain immunity. The glymphatic system enables bulk movement of CSF from the subarachnoid space along periarterial spaces, …
As such, the glymphatic system plays a key role in regulating directional interstitial fluid movement, waste clearance, and, potentia …
Glymphatic clearance function in patients with cerebral small vessel disease.
Zhang W, Zhou Y, Wang J, Gong X, Chen Z, Zhang X, Cai J, Chen S, Fang L, Sun J, Lou M. Zhang W, et al. Neuroimage. 2021 Sep;238:118257. doi: 10.1016/j.neuroimage.2021.118257. Epub 2021 Jun 10. Neuroimage. 2021. PMID: 34118396 Free article.

Among 39 patients included in study 1, mALPS-index were significantly related to glymphatic clearance function calculated on Glymphatic MRI ( r = -0.772~-0.844, p < 0.001). ...Our results indicated that non-invasive mALPS-index might represent glymphatic clearance

…
Among 39 patients included in study 1, mALPS-index were significantly related to glymphatic clearance function calculated on Glymphat …
Perivascular space dilation is associated with vascular amyloid-beta accumulation in the overlying cortex.
Perosa V, Oltmer J, Munting LP, Freeze WM, Auger CA, Scherlek AA, van der Kouwe AJ, Iglesias JE, Atzeni A, Bacskai BJ, Viswanathan A, Frosch MP, Greenberg SM, van Veluw SJ. Perosa V, et al. Acta Neuropathol. 2022 Mar;143(3):331-348. doi: 10.1007/s00401-021-02393-1. Epub 2021 Dec 20. Acta Neuropathol. 2022. PMID: 34928427 Free PMC article.
Perivascular spaces (PVS) are compartments surrounding cerebral blood vessels that become visible on MRI when enlarged. ...Overall, these findings are consistent with the notion that EPVS reflect impaired outward flow along arterioles and have implications for our understa …
Perivascular spaces (PVS) are compartments surrounding cerebral blood vessels that become visible on MRI when enlarged. ...Overall, t …
4,242 results